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Heavy smokers who consumed a pack or more daily typically have high tolerance levels

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Associations between the intensity of maternal cigarette smoking and birth congenital anomalies Compared with non-smokers, infants born to women who consumed any number of cigarettes per day before or during pregnancy, even only 15 cigarettes per day, had an increased risk of four subtypes of congenital anomalies, including gastroschisis, limb reduction defect, cleft lip with or without cleft palate, and cleft palate alone

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